Comparison and functional characterization of peripheral blood mononuclear cells isolated from filarial lymphedema and endemic normals of a South Indian population.
Identifieur interne : 000692 ( Main/Exploration ); précédent : 000691; suivant : 000693Comparison and functional characterization of peripheral blood mononuclear cells isolated from filarial lymphedema and endemic normals of a South Indian population.
Auteurs : Abel Arul Nathan [Inde] ; Madhulika Dixit [Inde] ; Subash Babu [Inde] ; Anand Setty Balakrishnan [Inde]Source :
- Tropical medicine & international health : TM & IH [ 1365-3156 ] ; 2017.
Abstract
The underlying problem in lymphatic filariasis is irreversible swelling of the limbs (lymphedema), which is a unique feature of lymphatic insufficiency. It is still unclear whether the natural ability of lymphatics to form functional lymphatic vasculature is achieved or attenuated in the lymphedemal pathology. Clinical studies have clearly shown that circulating lymphatic progenitors (CLPs), a subset of bone-marrow derived mononuclear cells (PBMCs), contribute to post-natal lymph vasculogenesis. CLP-based revascularization could be a promising strategy to bypass the endothelial disruption and damage incurred by the filarial parasites. Thus our aim was to compare and characterize the functional prowess of PBMCs in physiological and lymphedemal pathology.
DOI: 10.1111/tmi.12969
PubMed: 28869696
Affiliations:
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